Lana Condor

Ruby Gillman (voice)

Toni Collette

Agatha Gillman (voice)

Annie Murphy

Chelsea Van Der Zee (voice)

Sam Richardson

Uncle Brill (voice)

Liza Koshy

Margo (voice)

Will Forte

Gordon Lighthouse (voice)

Colman Domingo

Arthur Gillman (voice)

Jaboukie Young-White

Connor (voice)

Blue Chapman

Sam Gillman (voice)

Ramona Young

Bliss (voice)

Eduardo Franco

Trevin (voice)

Jane Fonda

Grandmamah (voice)